Aspergillosis differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Aspergillosis must be differentiated from other diseases that cause fever, chest pain, dyspnea, sinusitis, allergic symptoms, and elevated IgE concentrations. Differential diagnosis includes other infections (fungi, bacteria, viruses, and parasites), non-infectious pulmonary diseases (such as asthma, COPD, interstitial lung disease, bronchiectasis, and lung malignancy), cardiac diseases (such as pericarditis, endocarditis, or myocarditis), facial diseases (such as infectious sinusitis, sinus tumor, or nasal polyps), systemic diseases (such as HyperIgE syndrome, Churg Strauss syndrome, granulomatosis with polyangiitis, Goodpasture's syndrome), congenital diseases (such as cystic fibrosis or cilinary dyskinesia), transplant-related complications (such as GVHD), diseases with cutaneous manifestations (such as eczema, scabies, deep vein thrombosis, cellulitis), and adverse drug reactions.
Diffential Diagnosis
Aspergillosis must be differentiated from other diseases that cause fever, chest pain, dyspnea, sinusitis, allergic symptoms, and elevated IgE concentrations. Differential diagnosis includes:
- Actinomycosis
- Acute Respiratory Distress Syndrome
- Aspiration (e.g. foreign body)
- Asthma
- Arteriovenous malformation
- Blastomycosis
- Bronchiectasis and mucoid impaction
- Bronchocentric granulomatosis
- Cellulitis
- Churg Strauss syndrome
- Coccidiomycosis
- COPD exacerbation
- Cryptocococcus
- Ciliary dyskinesia
- Cystic fibrosis
- Deep vein thrombosis
- Drug adverse reaction
- Eczma
- Endocarditis
- Eosinophilia
- Eosinophilic pneumonia
- Goodpasture's syndrome
- Granulocytopenia
- Granulomatosis with polyangiitis (Wegener granulomatosis)
- Graft vs. host disease
- Heart failure
- Hemosiderosis
- Hemothorax
- Histoplasmosis
- Histioccytosis
- Hypereosinophilic syndrome
- Hypersensitivity Pneumonitis
- HyperIgE syndrome
- Impetigo
- Infectious sinusitis
- Interstitial lung disease
- Leishmeniasis
- Leproma
- Leukemia
- Loffler syndrome
- Lung Abscess
- Lung tumor (primary or metastatic)
- Lymphoma
- Malaria
- Mucormycosis
- Myeloproliferative disorder
- Myocardial abscess
- Myocarditis
- Nasopharyngeal polyp
- Nocardiosis
- Parasitic infection
- Paracoccidiodomycosis
- Pericarditis
- Pneumonia
- Pneumothorax
- Pulmonary embolism
- Pulmonary eosinophilia
- Pulmonary arterial hypertension
- Sarcoidosis
- Scabies
- Scedosporiosis
- Sporotrichosis
- Sinus tumor
- Trauma
- Tuberculosis (including tuberculoma)
- Zygomycosis