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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]

Epidemiology and Demographics

It is estimated that every year 2 million pregnant women are infected with syphilis every year.
In 2005, WHO reported that 460,000 abortions or still birth and 270,000 cases of congenital syphilis every year can be attributed to maternal syphilis.
The incidence of congenital syphilis in United States in the year 2014 is 11.6 cases per 100,000 live births. The incidence of congenital syphilis has increased when compared to the numbers from 2008 to 2012 and the change is attributed to the increase in the number of women with primary and secondary syphilis.^[1]^[2]

Congenital syphilis is ten times more prevalent in African American population compared to whites and three times more common in blacks compared to Hispanics.

From 2005 to 2008, most of the increase in CS cases and CS rate occurred among infants born to black mothers. The number of cases in this population increased from 156 in 2005 to 215 in 2008, and the CS rate increased 30%, from 26.6 per 100,000 live births in 2005 to 34.6 in 2008. The increase in rates among infants born to black mothers was observed primarily in the South. In 2005, 79 (51%) of the 156 infants with CS born to black mothers were born in the South; that percentage increased to 75% (162 of 215 infants) in 2008.

From 2005 to 2008, the CS rate among infants born to Hispanic mothers increased 2%, from 12.6 per 100,000 live births to 12.8. The rate among infants born to white mothers increased 115%, from 1.3 per 100,000 live births to 2.8; however, the number of cases was small (31 in 2005 and 65 in 2008). In 2008, infants of black mothers accounted for 50% of CS cases, infants of Hispanic mothers accounted for 31% of cases, and infants of white, Asian/Pacific Islander, and American Indian/Alaskan Native mothers accounted for 15%, 2%, and 1%, respectively.

↑ Peterman TA, Su J, Bernstein KT, Weinstock H (2015). "Syphilis in the United States: on the rise?". Expert Rev Anti Infect Ther. 13 (2): 161–8. doi:10.1586/14787210.2015.990384. PMID 25487961.
↑ Bowen V, Su J, Torrone E, Kidd S, Weinstock H (2015). "Increase in incidence of congenital syphilis - United States, 2012-2014". MMWR Morb Mortal Wkly Rep. 64 (44): 1241–5. doi:10.15585/mmwr.mm6444a3. PMID 26562206.