Primary biliary cirrhosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Laboratory Findings
To diagnose PBC, distinctions should be established from other conditions with similar symptoms, such as autoimmune hepatitis or primary sclerosing cholangitis (PSC).
Diagnostic blood tests include:
- Deranged liver function tests (high alkaline phosphatase, elevated AST, ALT)
- Presence of certain antibodies: antimitochondrial antibody antinuclear antibodies like anti-glycoprotein-210 antibodies, anti-centromere antibodies, anti-sp100. (the M2-IgG antimitochondrial antibody is the most specific test)