Idiopathic interstitial pneumonia medical therapy
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Idiopathic Interstitial Pneumonia Microchapters |
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Differentiating Idiopathic interstitial pneumonia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2];
Overview
As IIPs are heterogenous group of unknown interstitial lung disease with different natural history and clinical course, their management should be based on the clinical subtype. Optimal therapy for IPF is controversial as all currently available medications for IPF are severely limited by the lack of clear understanding of the natural history of IPF, the presence of various forms of study designs; heterogeneous patient groups, disputable diagnostic certainty; variable study duration; differences in medication formulation, dosage, route of administration, and duration of treatment; lack of placebo controls; variable intervals between evaluations and differing types of non quantitative assessment criteria. To date, most of treatment strategies have been based on eliminating or suppressing the inflammatory component. As no pharmacological therapy has been proven a clinical efficacy in altering or reversing the inflammatory process of IPF.
Medical Therapy
Major Idiopathic Interstitial Pneumonias
Chronic Fibrosing IIPs
- Idiopathic Pulmonary Fibrosis
- poor response to corticosteroids and cytotoxic drugs
- Idiopathic Nonspecific Interstitial Pneumonia
- good response to corticosteroids
Acute/Subacute IIPs
- Cryptogenic Organizing Pneumonia
- good response to corticosteroids
- Acute Interstitial Pneumonia (Hamman-Rich Syndrome)
- unknown response to corticosteroids
- Respiratory Bronchiolitis-Interstitial Lung Disease
- good response to smoking cessation but unknown response to corticosteroids
- Desquamative Interstitial Pneumonia
- good response to smoking cessation but unknown response to corticosteroids