Chlorprothixene

Revision as of 17:53, 9 April 2015 by Kiran Singh (talk | contribs)
Jump to navigation Jump to search
Chlorprothixene
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Oral, IM
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismHepatic
Elimination half-life8–12 hours
ExcretionFeces, urine
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC18H18ClNS
Molar mass315.861 g/mol
3D model (JSmol)
  (verify)

WikiDoc Resources for Chlorprothixene

Articles

Most recent articles on Chlorprothixene

Most cited articles on Chlorprothixene

Review articles on Chlorprothixene

Articles on Chlorprothixene in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Chlorprothixene

Images of Chlorprothixene

Photos of Chlorprothixene

Podcasts & MP3s on Chlorprothixene

Videos on Chlorprothixene

Evidence Based Medicine

Cochrane Collaboration on Chlorprothixene

Bandolier on Chlorprothixene

TRIP on Chlorprothixene

Clinical Trials

Ongoing Trials on Chlorprothixene at Clinical Trials.gov

Trial results on Chlorprothixene

Clinical Trials on Chlorprothixene at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Chlorprothixene

NICE Guidance on Chlorprothixene

NHS PRODIGY Guidance

FDA on Chlorprothixene

CDC on Chlorprothixene

Books

Books on Chlorprothixene

News

Chlorprothixene in the news

Be alerted to news on Chlorprothixene

News trends on Chlorprothixene

Commentary

Blogs on Chlorprothixene

Definitions

Definitions of Chlorprothixene

Patient Resources / Community

Patient resources on Chlorprothixene

Discussion groups on Chlorprothixene

Patient Handouts on Chlorprothixene

Directions to Hospitals Treating Chlorprothixene

Risk calculators and risk factors for Chlorprothixene

Healthcare Provider Resources

Symptoms of Chlorprothixene

Causes & Risk Factors for Chlorprothixene

Diagnostic studies for Chlorprothixene

Treatment of Chlorprothixene

Continuing Medical Education (CME)

CME Programs on Chlorprothixene

International

Chlorprothixene en Espanol

Chlorprothixene en Francais

Business

Chlorprothixene in the Marketplace

Patents on Chlorprothixene

Experimental / Informatics

List of terms related to Chlorprothixene

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chlorprothixene (Cloxan, Taractan, Truxal) is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized.[1] It was introduced in 1959 by Lundbeck.[2]

Chlorprothixene is not approved for use in the United States.

Pharmacology

Chlorprothixene exerts strong antagonism at the following receptors:

  • 5-HT2: antipsychotic effects, anxiolysis, weight gain
  • D1, D2, D3: antipsychotic effects, sedation, extrapyramidal side effects, prolactin increase, depression, apathy/anhedonia, weight gain
  • H1: sedation, weight gain
  • mACh: anticholinergic effects, inhibition of extrapyramidal side effects
  • α1-adrenergic: hypotension, tachycardia

Chlorprothixene does also act as FIASMA (functional inhibitor of acid sphingomyelinase).[3]

Indications

Chlorprothixene's principal indications are the treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occurring as part of bipolar disorders.

Other uses are pre- and postoperative states with anxiety and insomnia, severe nausea / emesis (in hospitalized patients), the amelioration of anxiety and agitation due to use of selective serotonin reuptake inhibitors for depression and, off-label, the amelioration of alcohol and opioid withdrawal. It may also be used cautiously to treat nonpsychotic irritability, aggression, and insomnia in pediatric patients.

An intrinsic antidepressant effect of chlorprothixene has been discussed, but not proven yet. Likewise, it is unclear, if chlorprothixene has genuine (intrinsic) analgesic effects. However, chlorprothixene can be used as comedication in severe chronic pain. Also, like most antipsychotics, chlorprothixene has antiemetic effects.

Side effects

Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side effects. The types of side effects encountered (dry mouth, massive hypotension and tachycardia, hyperhidrosis, substantial weight gain etc.) normally do not allow a full effective dose for the remission of psychotic disorders to be given. So cotreatment with another, more potent, antipsychotic agent is needed.

Chlorprothixene is structurally related to chlorpromazine, with which it shares, in principle, all side effects. Allergic side effects and liver damage seem to appear with an appreciable lower frequency. The elderly are particularly sensitive to anticholinergic side effects of chlorprothixene (precipitation of narrow angle glaucoma, severe obstipation, difficulties in urinating, confusional and delirant states). In patients >60 years the doses should be particularly low.

Early and late extrapyramidal side effects may occur but have been noted with a low frequency (one study with a great number of participants has delivered a total number of only 1%).

Overdosage

Overdose symptoms can be confusion, hypotension, and tachycardia, and several fatalities have been reported with concentrations in postmortem blood ranging from 0.1 to 7.0 mg/L compared to non-toxic levels in postmortem blood which can extend to 0.4 mg/kg. [4]

Dosage

The initial doses of chlorprothixene should always be as low as possible (e.g. 30 mg at bedtime, 15 mg morning dose) and be increased gradually. Patients receiving 90 mg daily (and more) of the drug should be hospitalized, particularly during the initial phase of treatment. The theoretical maximum is 800 mg daily which can usually not be given due to side effects as stated above. Elderly and pediatric patients should be treated with particular low initial doses. Dose increments should be done slowly. If chlorprothixene is to be withdrawn, it should not be stopped abruptly, but the dose should be decreased steadily.

Interactions

Chlorprothixene may increase the plasma-level of concomitantly given lithium. In order to avoid lithium intoxication, lithium plasma levels should be monitored closely.

If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side effects of opioids considerably.

Avoid the concomitant use of chlorprothixene and tramadol (Ultram). Seizures may be encountered with this combination.

Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbiturates. Choose particular low doses of these drugs.

Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma .

Synthesis

Chlorprothixene (2-chloro-9[(1-dimethylamino)-3-propyliden]thioxanthene) is made starting from 2-Chlorothioxanthone. 2-Chlorothioxantone, in turn, is prepared from 2-mercaptobenzoic acid (1), the reaction of which with 1-bromo-4-chlorobenzene (2) forms 2-(4-chlorophenylthio)benzoic acid 5, which upon reaction with phosphorus pentachloride transforms into acid chloride (6), and further undergoes intramolecular cyclization with the use of aluminum chloride to give 2-chlorthioxantone (6).[5]

An alternative way of making 2-chlorthioxantone (7) is by making 2-(4-chlorophenylthio)benzoic acid (5) by reacting 2-iodobenzoic acid (3) with 4-chlorothiophenol (4).[6]

File:2-Chlorothioxantone synthesis.svg
2-Chlorothioxantone synthesis: DE 1044103  U.S. Patent 2,951,082

The resulting 2-chlorothioxantone is reacted as a carbonyl component with either 3-dimethylaminopropylmagnesiumbromide (see Engelhardt above), or with allylmagnesiumbromide, giving the corresponding tertiary alcohols 8, and 9.

Chlorprothixene synthesis:Template:US Patent DE 1168446  DE 1418517 

Dehydration of the tertiary (8) is accomplished by acylation of the tertiary hydroxyl group using acetyl chloride and the subsequent pyrolysis of the formed acetate, which leads to the desired chlorprothixene. In the second case, dehydration of the tertiary alcohol (9) is accomplished by chlorination of the tertiary alcohol group by thionyl chloride, forming the diene 2-chloro-9-(3-propen-1-iliden)thioxanthene (10), the addition to which of dimethylamine at high temperature forms the desired chlorprothixene (11).

See also

References

  1. Healy, David (1997). The antidepressant era. Cambridge: Harvard University Press. p. 182. ISBN 0-674-03958-0.
  2. Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
  3. Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer T, Spitzer G, Liedl K, Gulbins E, Tripal P (2011). "Identification of novel functional inhibitors of acid sphingomyelinase". PLoS ONE. 6 (8): e23852. doi:10.1371/journal.pone.0023852. PMC 3166082. PMID 21909365.
  4. Skov L, Johansen SS, Linnet K (Jan 2015). "Postmortem Femoral Blood Reference Concentrations of Aripiprazole, Chlorprothixene, and Quetiapine". Journal of Analytical Toxicology. 39 (1): 41–44. doi:10.1093/jat/bku121.
  5. H. Spiegelberg, K. Doeben, DE 1044103  (1957).
  6. E.L. Engelhardt, J.M. Sprague, Template:US Patent (1960).

Template:Tricyclics