Nasopharyngeal carcinoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Faizan Sheraz, M.D. [2]
Overview
Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes: well-differentiated, moderately-differentiated, and undifferentiated type.
Classification
Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes:[1]
- Well-differentiated (keratinizing type)
- Moderately-differentiated (nonkeratinizing type)
- Undifferentiated (most strongly associated with Epstein-Barr virus infection)
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Undifferentiated nasopharyngeal carcinoma - low power
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Undifferentiated nasopharyngeal carcinoma - med. power
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Undifferentiated nasopharyngeal carcinoma - high power
Histologic subclassification
World Health Classification (2005) for NPC:[2]
Type | Histology | Description | EBV | Prevalence | Prognosis |
---|---|---|---|---|---|
1 | Keratinizing SCC | graded poorly-well-differentiated | -ve | bad | |
2a | Nonkeratinizing carcinoma, differentiated | well defined cell borders & tumour nest borders | +ve | good | |
2b | Nonkeratinizing carcinoma, undifferentiated | sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | most common | ||
3 | Basaloid SCC | mimics basal cell carcinoma | least common |
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma