Breast lumps causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

Breast lumps, or breast palpable masses, are the second most common breast symptoms, after mastalgia. These must be distinguished from the normal nodularity of the breast.[1] They can be of cystic or solid nature, which can’t be appropriately distinguished just based on physical examination.[2] Usually a breast lump is only palpable after reaching 2 cm of diameter.[3] Breast lumps are more commonly found in premenopausal women, becoming less frequent with age.[4] The most common etiologies are fibroadenomas, cysts and carcinomas. The probability of malignancy on a breast lump increases with age.[5] Factors like the woman’s age and physical characteristics of the mass, palpated by the clinician, may provide clues about its etiology on an initial assessment. However, a definitive diagnosis must be pursued, since all breast lumps warrant thorough evaluation.[6] Every palpable mass, whose benign nature cannot be appropriately determined by ultrasound, will require biopsy for tissue diagnosis. This also applies to lesions that cannot be visualized by mammography. The role of the mammography in this setting is also to look for other coincident lesions that may not be palpated.[7]

Causes

Life Threatening Causes

There are no life-threatening causes.

Common Causes

Causes by Organ System

Cardiovascular Mondor's disease
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Cysts of Montgomery, epithelioma of the nipple, hives, intraductal papilloma, lymphocytoma cutis, Paget's disease of the breast, retroareolar cyst, sclerosing adenosis, sebaceous cyst, skin lumps, Zuska's disease
Drug Side Effect Alefacept, cyclosporine, efalizumab, estradiol, estrogen, estrogen and progestin, etanercept, etonogestrel and ethinyl estradiol, medroxyprogesterone, norelgestromin and ethinyl estradiol, progestin
Ear Nose Throat No underlying causes
Endocrine Aberration of normal development and involution (ANDI), breast fibroadenoma, chronic cystic mastitis, fibro-adenosis of the newborn, fibroadenoma, galactocele, giant fibroadenoma, glandular thickening due to hormonal changes of pregnancy, gynecomastia, hyalinized fibroadenoma, premenstrual syndrome, simple cyst
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Aberration of normal development and involution (ANDI), adenoid cystic carcinoma, apocrine metaplasia, apocrine or squamous metaplasia, apocrine papillary carcinoma, ataxia-telangiectasia heterozygosity, breast cancer, cancer, colloidal breast cancer, Cowden syndrome, cyclosporine, cyst wall cancer, ductal carcinoma, extramedullary myeloid tumor, giant mammary hamartoma, hamartoma, hereditary diffuse gastric cancer, Hodgkin's disease, inflammatory breast cancer, juvenile secretory carcinoma, Li-Fraumeni syndrome, lymphoma, malignant carcinoma, medullary carcinoma, metastatic breast cancer, metastatic cancer, mucinous carcinoma, Peutz-Jeghers syndrome, primary breast cancer, PTEN hamartoma tumor syndrome
Hematologic Extramedullary myeloid tumor, Hodgkin's disease, lymphoma, medullary carcinoma, rhabdomyosarcoma, sarcoma, venous thrombosis
Iatrogenic Abscess, alefacept, breast abscess, breast fat necrosis, breast implant, complicated cyst, cyclosporine, efalizumab, estradiol, estrogen, estrogen and progestin, etanercept, etonogestrel and ethinyl estradiol, hematoma, medroxyprogesterone, norelgestromin and ethinyl estradiol, postoperative scar/hematoma, progestin, radial scar, radiation induced angiosarcoma of the breast
Infectious Disease Abscess, benign inflammatory periductal mastitis, breast abscess, tuberculosis of the breast
Musculoskeletal/Orthopedic No underlying causes
Neurologic Ataxia-telangiectasia heterozygosity
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic Aberration of normal development and involution (ANDI), adenoid cystic carcinoma, apocrine metaplasia, apocrine or squamous metaplasia, benign inflammatory periductal mastitis, apocrine papillary carcinoma, breast abscess, breast cancer, breast duct papilloma, breast fat necrosis, breast fibroadenoma, breast implant, breast injury,breast trauma, chronic cystic mastitis, colloidal breast cancer, complicated cyst, cowden syndrome, cyst wall cancer, cystosarcoma phyllodes, cysts of Montgomery, duct ectasia of breast, ductal carcinoma, epithelioma of the nipple, fat necrosis, fibro-adeno-lipoma, fibro-adenosis of the newborn, fibroadenoma, galactocele, giant fibroadenoma, giant mammary hamartoma, glandular thickening due to hormonal changes of pregnancy, gynecomastia, hyalinized fibroadenoma, intraductal papilloma, Li-Fraumeni syndrome, lobular neoplasia, lymphocytic mastitis, mammary duct ectasia, mastitis, metastatic breast cancer, mucinous carcinoma, paget's disease of the breast, periductal mastitis, phyllodes tumor, plasma cell mastitis, primary breast cancer, pseudoangiomatous stromal hyperplasia, retroareolar cyst, ruptured cyst or duct, sclerosing adenosis, tuberculosis of the breast, Zuska's disease
Oncologic Adenoid cystic carcinoma, apocrine papillary carcinoma, ataxia-telangiectasia heterozygosity, breast cancer, cancer, colloidal breast cancer, cyst wall cancer, cystosarcoma phyllodes, desmoplastic small round cell tumor, ductal carcinoma, epithelioma of the nipple, extramedullary myeloid tumor, hereditary diffuse gastric cancer, Hodgkin's disease, inflammatory breast cancer, juvenile secretory carcinoma, Li-Fraumeni syndrome, lymphoma, malignant carcinoma, medullary carcinoma, metastatic breast cancer, metastatic cancer, mucinous carcinoma, paget's disease of the breast, Peutz-Jeghers syndrome, phyllodes tumor, primary breast cancer, pten hamartoma tumor syndrome, radiation induced angiosarcoma of the breast, rhabdomyosarcoma, sarcoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Benign inflammatory periductal mastitis, cysts of Montgomery, desmoplastic small round cell tumor, hives, inflammatory breast cancer, intramammary lymph node, lymphatic obstruction, lymphocytoma cutis, lymphocytic mastitis, mastitis, Mondor's disease, periductal mastitis, plasma cell mastitis, Zuska's disease
Sexual No underlying causes
Trauma Breast fat necrosis, breast injury, breast trauma, fat necrosis, hematoma, ruptured cyst or duct, traumatic fat necrosis
Urologic No underlying causes
Miscellaneous Fibro-adeno-lipoma, hypertrophy, lipoma, lymphatic obstruction, oil cyst, postoperative scar/hematoma, radial scar, ruptured cyst or duct, venous thrombosis

Causes in Alphabetical Order

Causes

References

  1. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson.; Robbins, Stanley L. (Stanley Leonard); Cotran, Ramzi S. (2005). Robbins and Cotran pathologic basis of disea. Philadelphia: Elsevier Saunders. ISBN 978-0-7216-0187-8.
  2. ↑ Andreoli, Thomas E.; Cecil, Russell L. (Russell La Fayette) (2010). Andreoli and Carpenter's Cecil essentials of medicin. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1-4160-6109-0.
  3. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson.; Robbins, Stanley L. (Stanley Leonard); Cotran, Ramzi S. (2005). Robbins and Cotran pathologic basis of disea. Philadelphia: Elsevier Saunders. ISBN 978-0-7216-0187-8.
  4. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson.; Robbins, Stanley L. (Stanley Leonard); Cotran, Ramzi S. (2005). Robbins and Cotran pathologic basis of disea. Philadelphia: Elsevier Saunders. ISBN 978-0-7216-0187-8.
  5. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson.; Robbins, Stanley L. (Stanley Leonard); Cotran, Ramzi S. (2005). Robbins and Cotran pathologic basis of disea. Philadelphia: Elsevier Saunders. ISBN 978-0-7216-0187-8.
  6. ↑ Bickley, Lynn S.; Szilagyi, Peter G.; Bates, Barbara (2009). Bates' guide to physical examination and history taki. Philadelphia: Wolters Kluwer Health/Lippincott Williams Wilkins. ISBN 0-7817-8058-6.
  7. ↑ Andreoli, Thomas E.; Cecil, Russell L. (Russell La Fayette) (2010). Andreoli and Carpenter's Cecil essentials of medicin. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1-4160-6109-0.


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