Subependymal giant cell astrocytoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Pathophysiology

Genetic

Development of subependymal giant cell astrocytoma is the result of multiple genetic mutations.
Genes involved in the pathogenesis of subependymal giant cell astrocytoma include:

Associated Conditions

Subependymal giant cell astrocytoma may be associated with tuberous sclerosis.^[1]

Gross Pathology

On gross pathology, subependymal giant cell astrocytoma is characterized by:
Common intracranial sites associated with subependymal giant cell astrocytoma include:


Anatomical Location	Summary

Cerebellum Third ventricle Optic nerve Optic chiasm Hypothalamus Thalamus Basal ganglia Brain stem Fourth ventricle Spinal cord Cerebral hemispheres Supratentorial NOS	_{Neuroanatomical distribution of aneuploid pilocytic astrocytoma tumors favors non-cerebellar areas.^[2]}

Microscopic pathology

On microscopic histopathological analysis, subependymal giant cell astrocytoma is characterized by:

According to the WHO classification of tumors of the central nervous system, subependymal giant cell astrocytoma is classified into a WHO grade I tumor.

Immunohistochemistry

Subependymal giant cell astrocytoma is demonstrated by positivity to tumor markers such as:

Reference

↑ Associations of pilocytic astrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pilocytic-astrocytoma. Accessed on October 26, 2015
↑ "Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age". Oncotarget. 2015. doi:10.18632/oncotarget.5571. ISSN 1949-2553.

Template:WikiDoc Sources

[AssociationPA1-1] Associations of pilocytic astrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pilocytic-astrocytoma. Accessed on October 26, 2015

[locPA1-2] "Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age". Oncotarget. 2015. doi:10.18632/oncotarget.5571. ISSN 1949-2553.

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