Salivary gland tumor pathophysiology

	Salivary gland tumor Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

The pathophysiology of salivary gland tumors depends on the histological subtype.


Entity	Architecture	Morphology	Cell borders	Cytoplasm	Nucleus	Differential Diagnosis	Other

Pleomorphic adenoma	Variable	mixed proportion; must include: myoepithelium mesenchymal stroma epithelium (ductal cells) or chondromyxoid stroma	Variable	Variable	Plasmacytoid	Adenoid cystic carcinoma	Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells
Warthin tumor	Papillary, bilayer	Cuboid (basal), columnar (apical)	Clearly seen	Eosinophilic, abundant	Unremarkable	Sebaceous lymphadenoma	AKA papillary cystadenoma lymphomatosum
Basal cell adenoma	variable, islands surrounded by hyaline bands, lesion encapsulated	Basaloid	Subtle	Scant, hyperchromatic	Granular	Basal cell adenocarcinoma
Canalicular adenoma	Chains of cells	Cuboid or columnar	Subtle	Scant, hyperchromatic	Granular	Basal cell adenoma	Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63-
Sialoblastoma	variable, islands surrounded by loose fibrous stroma	Basaloid	Subtle	Scant, hyperchromatic	Granular	Adenoid cystic carcinoma	Basal cell adenocarcinoma