Fibroma pathophysiology

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Pathogenesis

Ovarian Fibroma

• The tumour belongs to the same histopathologic spectrum as an ovarian thecoma / ovarian fibrothecoma. Fibromas have no (or very few) thecal cells and no (or minimal) estrogen activity.
• It is composed of spindle cells forming variable amounts of collagen. Sectioning of a fibroma typically reveals a chalky-white surface that has a whorled appearance, similar to that of a uterine fibroid. Areas of oedema, occasionally with cyst formation, are also relatively common.

Associated Conditions

Ovarian Fibroma

• Ascites- 40% of cases
• Pleural effusions in a small percentage of cases.
• Meigs syndrome: consists of an ovarian fibroma with ascites and a pleural effusion
• Nevoid basal cell carcinoma syndrome 1 -75% of cases