Creutzfeldt-Jakob disease laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The diagnosis of CJD is suspected when there are typical clinical symptoms and signs such as rapidly progressing dementia with myoclonus. Analysis of CSF for 14-3-3 protein is done to establish probable diagnosis. Positive 14-3-3 protein in CSF analysis makes the diagnosis of CJD probable but it is not diagnostic of CJD.[1]
Laboratory Tests
- Routine laboratory tests are normal in Creutzfeldt Jakob disease. Liver function tests could be abnormal in some cases.[2]
- Presence of following protein markers in addition to 14-3-3 (in CSF) has also been associated with CJD:
- S-100
- Neuron specific enolase
- Tau protein[3]
References
- ↑ Muayqil, T.; Gronseth, G.; Camicioli, R. (2012). "Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology". Neurology. 79 (14): 1499–506. doi:10.1212/WNL.0b013e31826d5fc3. PMID 22993290. Unknown parameter
|month=ignored (help) - ↑ Tanaka, M.; Iizuka, O.; Yuasa, T. (1992). "Hepatic dysfunction in Creutzfeldt-Jakob disease". Neurology. 42 (6): 1249. PMID 1302460. Unknown parameter
|month=ignored (help) - ↑ Sanchez-Juan, P.; Green, A.; Ladogana, A.; Cuadrado-Corrales, N.; Sáanchez-Valle, R.; Mitrováa, E.; Stoeck, K.; Sklaviadis, T.; Kulczycki, J. (2006). "CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease". Neurology. 67 (4): 637–43. doi:10.1212/01.wnl.0000230159.67128.00. PMID 16924018. Unknown parameter
|month=ignored (help)