Sickle-cell disease epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Epidemiology and Demographics
Sickle cell disease is known to have a high prevalence in Africa (specifically the sub-Saharan region), India, and the Middle East. Difference regions of the world display different frequencies of genotypes of the various sickle cell subtypes. Sickle cell disease is a condition that largely affects people of African descent. In a study of three cohorts in Nigeria and Sudan, the frequency of HbSS was 88-96%. The frequency of HbSC was 4-12%.[1] It affects 1 in 400 African Americans, and a total of 89,000 Americans.[2] In contrast, people from India have a lower frequency of the HbSS genotype (30-70%) and a higher frequency of sickle cell-beta-thalassemia (HbSB) genotype.[1]
There is a high frequency of emergency department visits by patients with sickle cell disease. Over a two-year period, there were a total of 97.579 visits amongst 8 states.[2] Amongst these visits, 52,107 warranted hospitalization.
References
- ↑ 1.0 1.1 Saraf SL, Molokie RE, Nouraie M, Sable CA, Luchtman-Jones L, Ensing GJ; et al. (2014). "Differences in the clinical and genotypic presentation of sickle cell disease around the world". Paediatr Respir Rev. 15 (1): 4–12. doi:10.1016/j.prrv.2013.11.003. PMC 3944316. PMID 24361300.
- ↑ 2.0 2.1 Brandow AM, Liem R (2011). ""Sickle Cell Disease in the Emergency Department: Atypical Complications and Management"". Clin Pediatr Emerg Med. 12 (3): 202–212. doi:10.1016/j.cpem.2011.07.003. PMC 3172721. PMID 21927581.