Sickle-cell disease history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Symptoms of sickle-cell disease include mild pain in the arms an legs to severe pain from sickle cell crises and acute chest syndrome.
History
The location of vaso-occlusive episodes determines the types of symptoms a patient will experience. For example, vaso-occlusive crisis in the bones will cause bone pain. Bones, especially weight-bearing bones, are a common target of vaso-occlusive damage due to bone ischemia.
Symptoms
Symptoms of sickle-cell disease include:
- Pain and/or bone pain
- Dactylitis
- Blurry vision
- Persistent and painful erection
- Numbness
- Tingling
- Motor loss
- Speech deficits
- Gait disturbance
- Leg ulceration
- Jaundice
Acute chest crisis
In addition to the symptoms above, symptoms of acute chest crisis include:
- Fever
- Chest pain
- Labored breathing
- Fatigue
- [[Shortness of breath
- Pallor