Hand-foot-and-mouth disease history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]

Overview

It is characterized by fever, sores in the mouth, and a rash with blisters. HFMD begins with a mild fever, poor appetite, malaise ("feeling sick"), and frequently a sore throat.

Symptoms

• Fever
• Headache
• Loss of appetite
• Rash with very small blisters on hands, feet, and diaper area; may be tender or painful if pressed
  • One or 2 days after the fever begins, painful sores develop in the mouth.
  • They begin as small red spots that blister and then often become ulcers.
  • They are usually located on the tongue, gums, and inside of the cheeks.
  • The skin rash develops over 1 to 2 days with flat or raised red spots, some with blisters.
  • The rash does not itch, and it is usually located on the palms of the hands and soles of the feet. It may also appear on the buttocks.
  • A person with HFMD may have only the rash or the mouth ulcers.
• Sore throat
• Ulcers in the throat (including tonsils), mouth, and tongue