Microsporidiosis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]

Natural History

If left untreated,microsporidiosis is self resolving with complete recovery within 14 days in immunocompetent patients While in immunocompromised patients, disease is more prolonged and patients are more vulnerable to complications as malnutrition and vitamin defeciencies.

Complications

Complication might arise in immunocompromised patients due to chronic diarrhea:

• Dehydration
• Weight loss
• Nutritional defeciencies
• Acalculous cholecystitis
• Systemic spread to the brain, respiratory tract, urinary tract, etc.

Prognosis

• The prognosis is excellent among immunocompetent patients with self resolving of the disease within 2 weeks.
• In immunocompromised patients, the prognosis is less favorable with more vulnerability to develop systemic spread of the disease and complications.
• Mortality due to microspridiosis is mostly associated with systemic disease and in patients not receiving HAART.