Systemic lupus erythematosus risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Risk Factors
The underlying cause of this autoimmune disease is not clear. Clinical data shows that the onset of systemic lupus erythematosus is associated with the following factors:
- Female: SLE affects nine times as many women as men.
- Younger than 50
- Race: African Americans, Asians, and non-Causcasian race are affected more often than people from other races
- Drugs
- People with relatives who suffer from SLE, rheumatoid arthritis or thrombotic thrombocytopenic purpura are at a slightly higher risk than the general population[1]
- Infections can stimulates some antigen specific cells and lead to SLE disease:
- Epstein-Barr virus (EBV): may induce anti-DNA antibodies or even lupus-like symptoms. It is associated with higher risk of SLE and also triggering the active course of disease in children
- Trypanosomiasis or mycobacterial infections may have the same effect as EBV
- Ultraviolet (UV) light
- Cigarette smoking 11708417
- Crystalline silica exposure in work environment (e.g. cleaning powders, soil, pottery materials, cement etc.) 12124868
- Drug allergy 12464374
- Caring a pet (especially pet dog)
- Moderate alcohol drinking might be protective for SLE 18795396
References
- ↑ DiGeronimo, Theresa. New Hope for People with Lupus. Prima Publishing. 2002.