Graft-versus-host disease other diagnostic studies
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
Biopsies of the suspected organs can be used to help diagnose GvHD. A tissue diagnosis is not necessary, but helps a clinician make the diagnosis in the correct clinical context. The skin, liver, or GI tract can be readily biopsied.
Other Diagnostic Studies
The diagnosis of GvHD can be made at the histologic level via tissue biopsy. Biopsies of the suspected organs involved can aid in the diagnosis. The sensitivities of tissue biopsy is somewhat limited though, and nearly 40% of cases can be missed.[1]
- Skin: A skin biopsy will show findings such as vacuolar interface dermatitis. Skin biopsy is typically done via a punch biopsy at bedside, without the requirement of local or general anesthesia. This is the most readily obtainable biopsy as it is the least invasive.
- Liver: A liver biopsy can be obtained via transjugular or percutananeous approaches. This is a relatively invasive procedure that requires anesthesia and carries a risk for bleeding and bowel perforation.
- GI tract: Biopsies of the upper GI tract can be achieved via endoscopy, and biopsies of the lower GI tract can be achieved via colonoscopy or flexible sigmoidoscopy. This is a moderately invasive procedure that requires sedation and carries a moderate risk for bleeding.
References
- ↑ Qian L, Wu Z, Shen J (2013). "Advances in the treatment of acute graft-versus-host disease". J Cell Mol Med. 17 (8): 966–75. doi:10.1111/jcmm.12093. PMC 3780546. PMID 23802653.