Endometriosis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]
Overview
Endometriosis is defined as the presence of functional endometrial tissue outside the uterine cavity. The most common sites affected are the ovaries, broad ligaments and the surrounding pelvic structures. It can also affect distant sites such as the lungs, ureters and CNS. The exact pathogenesis of endometriosis is not clear and several theories have made an attempt to describe the pathogenesis. Sampson theory of retrograde menstruation, coelomic metaplasia theory, lymphatic and vascular dissemination theory explain the mechanisms of implantation and invasion of the endometrial tissue outside the uterine cavity. Endometriosis is a cause of dysmenorrhea and dyspareunia, it must be differentiated from other conditions presenting with similar features such as adenomyosis, pelvic inflammatory disease, pelvic congestion syndrome and sub mucosal uterine fibroids. The goal of medical therapy is pain management and reduction in the endometrial implant size. Therapeutic options include GnRH agonists and danazol. Surgical therapy is reserved for patients with severe disease, failure to improve with medical therapy.
Historical Perspective
The early descriptions of endometriosis were in the early 19th century, and it was described as adenomyomas. In 1920's endometriosis was differentiated from adenomyosis and a detailed description of the disease was given by Cullen and Sampson. Sampson proposed the theory of retrograde menstruation as the pathogenesis of the disease.
Classification
Endometriosis is classified into four stages of severity based on revised American Society for Reproductive Medicine scoring system. The staging is based on the distribution of the lesions and the presence of adhesions.
Pathophysiology
The exact pathogenesis of endometriosis is not clear and several theories have made an attempt to describe the pathogenesis. Sampson theory of retrograde menstruation, coelomic metaplasia theory, lymphatic and vascular dissemination theory explain the implantation and invasion of the endometrial tissue outside the uterine cavity. Immunologic factors and genetic factors are also thought play a role in the pathogenesis of endometriosis.
Causes
Exact cause of endometriosis is unknown, it is thought be multifactorial in origin.
Differential Diagnosis
Endometriosis is a cause of dysmenorrhea and dyspareunia, it must be differentiated from other conditions presenting with similar features such as adenomyosis, pelvic inflammatory disease, pelvic congestion syndrome and sub mucosal uterine fibroids.
Epidemiology and Demographics
Endometriosis affects approximately around 11% of the female population in the reproductive age group. It accounts for majority of cases with chronic pelvic pain and infertility.
Risk Factors
The risk factors predisposing women for the development of endometriosis include: early age of menarche, nulliparity, positive family history and presence of congenital cervical stenosis or obstructive lesions in the uterovaginal tract.
Screening
Standard screening for endometriosis is not recommended.
Natural History, Complications and Prognosis
Endometriosis is a condition affecting females in the reproductive age group. It has a wide spectrum of presentations, it can be asymptomatic or present with premenstrual spotting and cyclical abdominal pain or present with infertility or chronic pelvic pain or as deep endometriosis presenting with dyspareunia, dyschezia and cyclical rectal bleeding. Complications of endometriosis include infertility, fibrosis, chocolate cyst, and rarely affecting other organs such as lung.
Diagnosis
History and Symptoms
Endometriosis is a condition affecting women in the reproductive age group. The presenting features include cyclical abdominal pain, dysmenorrhea, pain with passing stools, and pain with intercourse.
Physical Examination
Examination findings on digital vaginal examination and speculum examination include: Fixed retroverted uterus, with palpable nodularity of the uterosacral ligaments and cul-de-sac with narrowing of the posterior fornix.
Laboratory Findings
Laboratory findings associated with endometriosis include features of iron deficiency anemia and increased levels of cancer antigen-125 and interleukin 1.
EKG
There are no specific EKG findings associated with endometriosis.
Chest X-Ray
There are no specific chest X-Ray findings associated with endometriosis.
CT
There are no specific CT findings associated with endometriosis.
MRI
MRI is useful for the assessment of the anatomical locations and severity of the disease. The typical appearance of endometriosis includes a characteristic hyperintensity on T1-weighted images and a hypointensity on T2-weighted images.
Ultrasound
There are no specific echocardiography findings associated with endometriosis.
Other Imaging Findings
There are no associated other imaging findings with endometriosis.
Other Diagnostic Studies
Diagnostic laparoscopy is the gold standard to assess the severity and extent of the disease. Transvaginal ultrasound is done in patients with a suspicion of endometriosis, it is helpful in differentiation of endometriomas from other cystic abnormalities of the pelvic structures.
Treatment
Medical Therapy
The primary goal of medical therapy is pain management and regression of the endometrial lesions. NSAIDS are useful for pain management. There are many therapeutic options available to reduce the size of endometrial lesions. Gonadotrophin releasing hormone agonists and danazol are widely used. Continuous oral contraceptive pill use is also helpful in patients with mild to moderate endometriosis.
Surgical Therapy
Patients with failed medical therapy and patients with stage 3 or stage 4 disease are candidates for surgical therapy. Laser and excision of the lesions is done for isolated lesions, total hysterectomy is reserved for patients with extensive disease.
Prevention
Primary Prevention
There are no primary preventive measures for endometriosis, however reduced intake of exogenous estrogen is advised for elderly women.
Secondary Prevention
There are no secondary preventive measures for endometriosis.