Growth hormone deficiency epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Epidemiology and Demographics

Incidence

• incidence rate of 1 case per 3,500 children. approximately 25% of the patients with growth hormone deficiency had an organic Mortality in children with growth hormone (GH) deficiency is due almost entirely to other pituitary hormone deficiencies. ^{null 1} These children have an increased relative risk of death in adulthood from cardiovascular causes resulting from altered body composition and dyslipidemia === Sex === The sex distribution of patients with idiopathic growth hormone deficiency is 73% male and 27% female. ^{[[null 4], [null 5], [null 6]]} Cuttler et al published results of a survey of pediatric endocrinologists that growth hormone treatment was 1.3 times more common in boys than in girls. ^{null 10} === Age === Diagnosis of growth hormone deficiency is made during 2 broad age peaks. The first age peak occurs at 5 years, a time when children begin school The second age peak occurs in girls aged 10-13 years and boys aged 12-16 years.