Growth hormone deficiency epidemiology and demographics

	Growth hormone deficiency Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Sex
The sex distribution of patients with idiopathic growth hormone deficiency is 73% male and 27% female. ^{[[null 4], [null 5], [null 6]]} Cuttler et al published results of a survey of pediatric endocrinologists that growth hormone treatment was 1.3 times more common in boys than in girls. ^{null 10}
Age
Diagnosis of growth hormone deficiency is made during 2 broad age peaks. The first age peak occurs at 5 years, a time when children begin school The second age peak occurs in girls aged 10-13 years and boys aged 12-16 years. While congenital GHD and most cases of idiopathic GHD are thought to be present from birth, diagnosis is often delayed until the patient’s short stature is noticed in relation to their peers. Race
There is no apparent racial difference in the incidence of GHD the National Cooperative Growth Study (NCGS) Genentech’s now closed large North American database, revealed that 85% of patients receiving GH treatment for idiopathic GHD were white, 6% were black, and 2% were Asian. Gender
Growth hormone deficiency affects males and females equally However, given the greater concern for boys with short stature in most societies, diagnosis tends to favor males over females. 73% of patients with idiopathic GHD in the NCGS were male. patients with GHD from organic causes such as tumors and radiation, in which no gender bias should be present, were still 62% male.