Microsporidiosis natural history, complications and prognosis

	Microsporidiosis Microchapters
Home
Patient Information
Overview
Historical perspective
Classification
Pathophysiology
Causes
Differentiating Microsporidiosis from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory findings
X ray
CT
MRI
Other imaging studies
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Microsporidiosis natural history, complications and prognosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Microsporidiosis natural history, complications and prognosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Microsporidiosis natural history, complications and prognosis
CDC on Microsporidiosis natural history, complications and prognosis
Microsporidiosis natural history, complications and prognosis in the news
Blogs on Microsporidiosis natural history, complications and prognosis
Directions to Hospitals Treating Microsporidiosis
Risk calculators and risk factors for Microsporidiosis natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]

Overview

If left untreated, immunocompetent patients resolve the disease completely within 2 weeks while immunocompromised patients might develop chronic diarrhea. Common complications of microsporidiosis include weight loss, dehydration, and acalculous cholecystitis. Prognosis is generally excellent in immunocompetent patients while immunocompromised patients are more vulnerable to developing chronic disease and complications.

Natural History

If left untreated, microsporidiosis is self-resolving with complete recovery within 14 days in immunocompetent patients. While in immunocompromised patients, the disease is more prolonged and patients are more vulnerable to complications such as malnutrition and vitamin deficiencies.^[1]

Complications

Complication might arise in immunocompromised patients due to chronic diarrhea:^[2]^[1]

Dehydration
Weight loss
Nutritional deficiencies
Acalculous cholecystitis
Systemic spread to the brain, respiratory tract, urinary tract, etc.

Prognosis

The prognosis is excellent among immunocompetent patients and the disease is self-limited within 2 weeks.
In immunocompromised patients, the prognosis is less favorable with more vulnerability to develop systemic spread of the disease and complications.
Mortality due to microsporidiosis is mostly associated with systemic disease and in AIDS patients not receiving HAART.

References

↑ ^1.0 ^1.1 van Hal SJ, Muthiah K, Matthews G, Harkness J, Stark D, Cooper D, Marriott D (2007). "Declining incidence of intestinal microsporidiosis and reduction in AIDS-related mortality following introduction of HAART in Sydney, Australia". Trans. R. Soc. Trop. Med. Hyg. 101 (11): 1096–100. doi:10.1016/j.trstmh.2007.06.003. PMID 17662322.
↑ Ramanan P, Pritt BS (2014). "Extraintestinal microsporidiosis". J. Clin. Microbiol. 52 (11): 3839–44. doi:10.1128/JCM.00971-14. PMC 4313212. PMID 24829239.

Template:WikiDoc Sources

[pmid17662322-1] 1.0 ^1.1 van Hal SJ, Muthiah K, Matthews G, Harkness J, Stark D, Cooper D, Marriott D (2007). "Declining incidence of intestinal microsporidiosis and reduction in AIDS-related mortality following introduction of HAART in Sydney, Australia". Trans. R. Soc. Trop. Med. Hyg. 101 (11): 1096–100. doi:10.1016/j.trstmh.2007.06.003. PMID 17662322.

[pmid24829239-2] Ramanan P, Pritt BS (2014). "Extraintestinal microsporidiosis". J. Clin. Microbiol. 52 (11): 3839–44. doi:10.1128/JCM.00971-14. PMC 4313212. PMID 24829239.

[1]

[2]