Hyperparathyroidism laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal among patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
Primary hyperparathyroidism
- An elevated serum ionized calcium on routine biochemical screening in a asymptomatic patient should raise the suspicion of primary hyperparathyroidism.
- An elevated/ concentration of serum ionized calcium with elevated parathyroid level is diagnostic of primary hyperparathyoidism.
- [Test] is usually normal among patients with [disease name].
- Laboratory findings consistent with the diagnosis of primary hyperparathyroidism include
- Elevated/ concentration of serum ionized calcium
- Elevated parathyroid level
- [Abnormal test 3]
- Some patients with primary hyperparathyroidism may have elevated concentration of serum parathyroid hormone with normal serum ionized calcium, which is usually suggestive of normocalcemic primary hyperparathyroidism. Causes of secondary hyperparathyroidism should be rules out for making the diagnosis of normocalcemic hyperparathyroidism.[1]
Secondary hyperparathyroidism
- Laboratory findings consistent with the diagnosis of secondary hyperparathyroidism include:
- Elevated serum parathyroid hormone level
- Low to normal serum ionized calcium
- Low serum vitamin D (25-hydroxy vitamin D) may be found if vitamin D deficiency is the cause of secondary hyperparathyroidism.
Tertiary hyperparathyroidism
- An elevated/ concentration of serum ionized calcium with elevated parathyroid level in post renal transplant patients is diagnostic of tertiary hyperparathyoidism.
References
- ↑ Silverberg SJ, Lewiecki EM, Mosekilde L, Peacock M, Rubin MR (2009). "Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop". J. Clin. Endocrinol. Metab. 94 (2): 351–65. doi:10.1210/jc.2008-1760. PMC 5393372. PMID 19193910.