Delayed puberty causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Causes
- Variation of normal (constitutional delay)
- Prolonged high level of physical exertion / being an athlete
- Systemic disease, e.g. Inflammatory bowel disease, chronic renal failure
- Undernutrition e.g. anorexia nervosa, zinc deficiency
- Hypothalamic defects and diseases e.g. Prader-Willi syndrome,Kallmann syndrome
- Pituitary defects and diseases e.g. hypopituitarism
- Gonadal defects and diseases e.g. Turner syndrome, Klinefelter syndrome
- Absence or unresponsiveness of target organs e.g. androgen insensitivity syndrome, mullerian agenesis
- Other hormone deficiencies and imbalances e.g. hypothyroidism, Cushing's syndrome