Cretinism classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Cretinism may be classified into two groups which include transient and permanent cretinism. Permanent cretinism may classified into two subgroups including primary and secondary cretinism.

Classification

• Cretinism may be classified based on the duration of thyroid hormones deficiency into two groups:
  • Transient cretinism: Transient deficiency of the thyroid hormones which may be discovered at birth. Thyroid hormone levels returns back to normal after a period of time.
  • Permanent cretinism: Permanent deficiency of the thyroid hormones which requires life long hormonal replacement. Permanent cretinism can be classified into two subgroups based on the location of the etiology:
    • Primary permanent cretinism
    • Secondary (central) permanent cretinism