Toxic megacolon historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Historical Perspective

Discovery

• In 1950, Marshak was the first to discover the association between Clostridium difficile and the development of toxic megacolon.

Landmark Events in the Development of Treatment Strategies

Jalen criteria was developed by Jalen et al to diagnose toxic megacolon.