Vascular endothelial growth factor C

Vascular endothelial growth factor C
Identifiers
Symbols	VEGFC ; Flt4-L; VRP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3962
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VEGFC 209946 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vascular endothelial growth factor C is a VEGF. VEGFC is the human gene encoding it.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

Further reading

• Orpana A, Salven P (2003). "Angiogenic and lymphangiogenic molecules in hematological malignancies". Leuk. Lymphoma. 43 (2): 219–24. PMID 11999550.
• Joukov V, Pajusola K, Kaipainen A; et al. (1996). "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". EMBO J. 15 (7): 1751. PMID 8612600.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joukov V, Pajusola K, Kaipainen A; et al. (1996). "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". EMBO J. 15 (2): 290–98. PMID 8617204.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paavonen K, Horelli-Kuitunen N, Chilov D; et al. (1996). "Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively". Circulation. 93 (6): 1079–82. PMID 8653826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee J, Gray A, Yuan J; et al. (1996). "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 1988–92. PMID 8700872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joukov V, Sorsa T, Kumar V; et al. (1997). "Proteolytic processing regulates receptor specificity and activity of VEGF-C". EMBO J. 16 (13): 3898–911. doi:10.1093/emboj/16.13.3898. PMID 9233800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fitz LJ, Morris JC, Towler P; et al. (1997). "Characterization of murine Flt4 ligand/VEGF-C". Oncogene. 15 (5): 613–8. doi:10.1038/sj.onc.1201191. PMID 9247316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunk C, Ahmed A (2001). "Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast". Histol. Histopathol. 16 (2): 359–75. PMID 11332691.
• Dias S, Choy M, Alitalo K, Rafii S (2002). "Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy". Blood. 99 (6): 2179–84. PMID 11877295.CS1 maint: Multiple names: authors list (link)
• Ueda M, Terai Y, Yamashita Y; et al. (2002). "Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas". Int. J. Cancer. 98 (3): 335–43. PMID 11920583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Witte D, Thomas A, Ali N; et al. (2002). "Expression of the vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C in human colorectal adenocarcinoma". Anticancer Res. 22 (3): 1463–6. PMID 12168824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schoppmann SF, Birner P, Stöckl J; et al. (2002). "Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis". Am. J. Pathol. 161 (3): 947–56. PMID 12213723.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shin HY, Smith ML, Toy KJ; et al. (2002). "VEGF-C mediates cyclic pressure-induced endothelial cell proliferation". Physiol. Genomics. 11 (3): 245–51. doi:10.1152/physiolgenomics.00068.2002. PMID 12388793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu DH, Wen YM, Sun JD; et al. (2003). "[Relationship among expression of vascular endothelial growth factor-C(VEGF-C), angiogenesis, lymphangiogenesis, and lymphatic metastasis in oral cancer]". Ai Zheng. 21 (3): 319–22. PMID 12452004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakashima T, Kondoh S, Kitoh H; et al. (2003). "Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasis". Int. J. Mol. Med. 11 (1): 33–9. PMID 12469214.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai PW, Shiah SG, Lin MT; et al. (2003). "Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway". J. Biol. Chem. 278 (8): 5750–9. doi:10.1074/jbc.M204863200. PMID 12471041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masood R, Kundra A, Zhu S; et al. (2003). "Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops". Int. J. Cancer. 104 (5): 603–10. doi:10.1002/ijc.10996. PMID 12594815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohno M, Nakamura T, Kunimoto Y; et al. (2004). "Lymphagenesis correlates with expression of vascular endothelial growth factor-C in colorectal cancer". Oncol. Rep. 10 (4): 939–43. PMID 12792749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)