TANK-binding kinase 1

TANK-binding kinase 1
Identifiers
Symbols	TBK1 ; FLJ11330; NAK; T2K
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22742
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TBK1 218520 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

TANK-binding kinase 1, also known as TBK1, is a human gene.

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Further reading

{{PBB_Further_reading | citations =

• Chou MM, Hanafusa H (1995). "A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain". J. Biol. Chem. 270 (13): 7359–64. PMID 7706279.
• Chen ZJ, Parent L, Maniatis T (1996). "Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity". Cell. 84 (6): 853–62. PMID 8601309.CS1 maint: Multiple names: authors list (link)
• Zandi E, Chen Y, Karin M (1998). "Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate". Science. 281 (5381): 1360–3. PMID 9721103.CS1 maint: Multiple names: authors list (link)
• Pomerantz JL, Baltimore D (2000). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMID 10581243.
• Tojima Y, Fujimoto A, Delhase M; et al. (2000). "NAK is an IkappaB kinase-activating kinase". Nature. 404 (6779): 778–82. doi:10.1038/35008109. PMID 10783893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonnard M, Mirtsos C, Suzuki S; et al. (2000). "Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription". EMBO J. 19 (18): 4976–85. doi:10.1093/emboj/19.18.4976. PMID 10990461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kishore N, Huynh QK, Mathialagan S; et al. (2002). "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2". J. Biol. Chem. 277 (16): 13840–7. doi:10.1074/jbc.M110474200. PMID 11839743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chariot A, Leonardi A, Muller J; et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li SF, Fujita F, Hirai M; et al. (2003). "Genomic structure and characterization of the promoter region of the human NAK gene". Gene. 304: 57–64. PMID 12568715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fitzgerald KA, McWhirter SM, Faia KL; et al. (2003). "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway". Nat. Immunol. 4 (5): 491–6. doi:10.1038/ni921. PMID 12692549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharma S, tenOever BR, Grandvaux N; et al. (2003). "Triggering the interferon antiviral response through an IKK-related pathway". Science. 300 (5622): 1148–51. doi:10.1126/science.1081315. PMID 12702806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato S, Sugiyama M, Yamamoto M; et al. (2004). "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling". J. Immunol. 171 (8): 4304–10. PMID 14530355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita F, Taniguchi Y, Kato T; et al. (2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling". Mol. Cell. Biol. 23 (21): 7780–93. PMID 14560022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• tenOever BR, Sharma S, Zou W; et al. (2004). "Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity". J. Virol. 78 (19): 10636–49. doi:10.1128/JVI.78.19.10636-10649.2004. PMID 15367631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuai J, Wooters J, Hall JP; et al. (2005). "NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach". J. Biol. Chem. 279 (51): 53266–71. doi:10.1074/jbc.M411037200. PMID 15485837.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• {{cite journal | author=Buss H, Dörrie A, Schmitz ML, et al. |title=Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55633-43 |year= 2005 |pmid= 15489227 |doi= 10.1074/jbc.M409825200 }}

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