MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Identifiers
Symbols	MFNG ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1803
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE MFNG 204153 s at tn.png
File:PBB GE MFNG 204152 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, also known as MFNG, is a human gene.

This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.

Further reading

• Johnston SH, Rauskolb C, Wilson R; et al. (1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development. 124 (11): 2245–54. PMID 9187150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen B, Bashirullah A, Dagnino L; et al. (1997). "Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila". Nat. Genet. 16 (3): 283–8. doi:10.1038/ng0797-283. PMID 9207795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Egan S, Herbrick JA, Tsui LC; et al. (1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics. 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moran JL, Johnston SH, Rauskolb C; et al. (1999). "Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes". Mamm. Genome. 10 (6): 535–41. PMID 10341080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Tine BA, Knops J, Shaw GM, May WA (2000). "Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH)". Cytogenet. Cell Genet. 87 (1–2): 132–3. PMID 10640833.CS1 maint: Multiple names: authors list (link)
• Moloney DJ, Panin VM, Johnston SH; et al. (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 (6794): 369–75. doi:10.1038/35019000. PMID 10935626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu K, Chiba S, Saito T; et al. (2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thélu J, Rossio P, Favier B (2003). "Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing". BMC Dermatol. 2: 7. PMID 11978185.CS1 maint: Multiple names: authors list (link)
• Panin VM, Shao L, Lei L; et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shao L, Moloney DJ, Haltiwanger R (2003). "Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region". J. Biol. Chem. 278 (10): 7775–82. doi:10.1074/jbc.M212221200. PMID 12486116.CS1 maint: Multiple names: authors list (link)
• Veeraraghavalu K, Pett M, Kumar RV; et al. (2004). "Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation". J. Virol. 78 (16): 8687–700. doi:10.1128/JVI.78.16.8687-8700.2004. PMID 15280477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)