CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)
PDB rendering based on 1ohc.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ohc​, 1ohd​, 1ohe​
Identifiers
Symbols	CDC14B ; CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 75343
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CDC14 cell division cycle 14 homolog B (S. cerevisiae), also known as CDC14B, is a human gene.

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Li L, Ernsting BR, Wishart MJ; et al. (1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J. Biol. Chem. 272 (47): 29403–6. PMID 9367992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li L, Ljungman M, Dixon JE (2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4): 2410–4. PMID 10644693.CS1 maint: Multiple names: authors list (link)
• Mailand N, Lukas C, Kaiser BK; et al. (2002). "Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation". Nat. Cell Biol. 4 (4): 317–22. doi:10.1038/ncb777. PMID 11901424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK (2003). "Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase". Mol. Biol. Cell. 13 (7): 2289–300. doi:10.1091/mbc.01-11-0535. PMID 12134069.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dryden SC, Nahhas FA, Nowak JE; et al. (2003). "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Mol. Cell. Biol. 23 (9): 3173–85. PMID 12697818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gray CH, Good VM, Tonks NK, Barford D (2003). "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22 (14): 3524–35. doi:10.1093/emboj/cdg348. PMID 12853468.CS1 maint: Multiple names: authors list (link)
• Nalepa G, Harper JW (2005). "Visualization of a highly organized intranuclear network of filaments in living mammalian cells". Cell Motil. Cytoskeleton. 59 (2): 94–108. doi:10.1002/cm.20023. PMID 15362113.
• Cho HP, Liu Y, Gomez M; et al. (2005). "The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules". Mol. Cell. Biol. 25 (11): 4541–51. doi:10.1128/MCB.25.11.4541-4551.2005. PMID 15899858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP (2005). "Functional homology among human and fission yeast Cdc14 phosphatases". J. Biol. Chem. 280 (32): 29144–50. doi:10.1074/jbc.M413328200. PMID 15911625.CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)