Esophageal cancer screening
|
Esophageal cancer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Esophageal cancer screening On the Web |
|
American Roentgen Ray Society Images of Esophageal cancer screening |
|
Risk calculators and risk factors for Esophageal cancer screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Screening may be effective in reducing the incidence of esophageal cancer, especially in Barrett's esophagus-associated adenocarcinoma, however, not very cost effective.
Screening
Adenocarcinoma screening
- The predominant type of esophageal cancer in the United States is adenocarcinoma.
- Screening is recommended for white men over the age of 50 years.[1]
- Screening should include random endoscopic biopsies taken in all 4 quadrants with a high resolution endoscope once in a lifetime.
- It should also be noted that those who present with adenocarcinoma demonstrate no prior Barrett's esophagus in 80 - 90% of the time.
Squamous cell carcinoma screening
Squamous cell carcinoma of the esophagus is more prevalent in underdeveloped countries; there is no reliable data to suggest that screening programs are effective when implemented.
- A screening program in a high risk population was established in Hishun village,China.
- Those with mild to moderate dysplasia were examined via endoscopy every 3 years, whilst those with severe dysplasia were screened once per year.
- All the patients were concomitantly treated with monoclonal antibodies for the next three years.
- At the end of three year monoclonal antibody trial, the incidence rate of esophageal squamous cell carcinoma had decreased by 57% in comparison to previous incidence rates.
- These results demonstrated that screening for dysplastic changes in the esophagus is effective in the prevention of esophageal squamous cell carcinoma.[2]
References
- ↑ Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á (2015). "Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries". World J. Gastroenterol. 21 (26): 7933–43. doi:10.3748/wjg.v21.i26.7933. PMC 4499337. PMID 26185366.
- ↑ Lin PZ, Zhang JS, Cao SG, Rong ZP, Gao RQ, Han R, Shu SP (1988). "[Secondary prevention of esophageal cancer--intervention on precancerous lesions of the esophagus]". Zhonghua Zhong Liu Za Zhi (in Chinese). 10 (3): 161–6. PMID 3219974.