Multiple sclerosis causes
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Overview
Causes
Multiple sclerosis may be caused by:
Autoimmunity:
The main hypothesis regarding MS etiology is that it is caused by an autoimmune reaction against central nervous system (CNS). Self reactive T cells which has been activated by a foreign (virus for example) or native factor, will attack the myelin sheath around the neurons. Presents of autoreactive T cells and myelin basic protein-specific CD4+ T cells in the peripheral blood smear of MS patients supports the autoimmune hypothesis.