Liver mass biopsy
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Liver Mass Microchapters |
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Liver mass biopsy On the Web |
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American Roentgen Ray Society Images of Liver mass biopsy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Liver biopsy is the gold standard test for the diagnosis of liver mass. Common indications for biopsy in liver mass, include: suspected hepatocellular carcinoma, and unspecific imaging findings. The most important contraindication for biopsy in liver mass is suspected liver hemangioma.[1][2]
Biopsy
Biopsy is always indicated in patients presenting with liver mass to rule out malignancy. Biopsy findings associated with liver mass will depend on tumor histology. [2]
Indications
- Indications for biopsy in liver mass, include:
- Suspected hepatocellular carcinoma[2]
- Suspected hepatic adenoma
- Focal nodular hyperplasia
- Unspecific and inconclusive liver mass imaging findings
Types
- Per-cutaneous, ultrasound-guided liver biopsy
- Laparoscopic liver biopsy
- Transjugular liver biopsy
| DIsease | Findings on Biopsy |
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| Focal nodular hyperplasia | Ductular reaction with varied intensity at the junction of the fibrous septa with the hepatocellular component, |
| Hepato-cellular carcinoma | Two out of the following three positive stains upon liver biopsy confirm HCC:[3][4] |
| Cirrhosis |
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Contraindications
- Contraindications for biopsy in liver mass, include:[2]
- Suspected hemangioma
- Adenomas
- Patients on of anticoagulant therapy
- Unstable medical conditions (eg. acute heart failure)
Complications
Complications for for biopsy in liver mass, include:[2]
- Bleeding
- Seeding of neoplastic cell
References
- ↑ Hepatocellular carcinoma. Libre Pathology.https://librepathology.org/wiki/Hepatocellular_carcinoma Accessed on March 28, 2016
- ↑ 2.0 2.1 2.2 2.3 2.4 Borzio M, Borzio F, Macchi R, Croce AM, Bruno S, Ferrari A, Servida E (1994). "The evaluation of fine-needle procedures for the diagnosis of focal liver lesions in cirrhosis". J. Hepatol. 20 (1): 117–21. PMID 8201212.
- ↑ "Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia". Hepatology. 49 (2): 658–64. 2009. doi:10.1002/hep.22709. PMID 19177576.
- ↑ Karabork A, Kaygusuz G, Ekinci C (2010). "The best immunohistochemical panel for differentiating hepatocellular carcinoma from metastatic adenocarcinoma". Pathol. Res. Pract. 206 (8): 572–7. doi:10.1016/j.prp.2010.03.004. PMID 20400233.