Oral cancer risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

The most potent risk factor in the development of oral cancer is alcohol intake and tobacco use. The other risk factors include male gender, age over 55 year, ultraviolet light, Fanconi anemia, dyskeratosis congenita, HPV infection, graft-versus-host disease (GVHD), mouthwash and irritation from dentures.

Risk Factors

• The most potent risk factor in the development of oral cavity cancer is tobacco and alcohol use.
• Other risk factors include:
  • Lifestyle
    • Betel quid
  • Genetics
    • Fanconi anemia
    • Dyskeratosis congenita
    • Family history of squamous cell carcinoma
• General
  • Male gender
  • Ultraviolet light
  • Age over 55 year
  • Human papillomavirus (HPV) infection: Infection with the human papillomavirus (HPV), especially HPV type 16, also known as HPV-16.
  • Graft-versus-host disease(GVHD)
  • Immune system suppression
  • Lichen planus
• Unproven risk factors
  • Mouthwash
  • Irritation from dentures

References

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