Osteoarthritis causes Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Robert G. Badgett, M.D. [2] Luke Rusowicz-Orazem, B.S.
Overview Causes Osteoarthritis (OA) occurs when the cartilage that cushions the ends of bones in your joints gradually deteriorates. Cartilage is a firm, slippery tissue that permits nearly frictionless joint motion.
In osteoarthritis, the slick surface of the cartilage becomes rough. Eventually, if the cartilage wears down completely, you may be left with bone rubbing on bone.
Osteoarthritis is the clinical and pathological outcome of a range of disorders that results in structural and functional failure of synovial joints.2 Traditionally, it has been considered a disease of articular cartilage. The current concept holds that osteoarthritis involves the entire joint organ, including the subchondral bone, menisci, ligaments, periarticular muscle, capsule, and synovium
Causes by Organ System
Cardiovascular
No underlying causes
Chemical/Poisoning
No underlying causes
Dental
No underlying causes
Dermatologic
Paget disease
Drug Side Effect
No underlying causes
Ear Nose Throat
No underlying causes
Endocrine
Acromegaly , Hemochromatosis , hyperparathyroidism , Pituitary cancer , Pituitary tumors , Reduced sex hormones
Environmental
No underlying causes
Gastroenterologic
Hemochromatosis , Wilson disease
Genetic
Adam12 , Alkaptonuria , Asymmetric leg length , Bmp , Clip , Col11a2 , Ehlers-danlos syndrome , Erg , Familial chondrocalcinosis , Frzb , Gdf5 , Il10 , Larsen syndrome , Mcf2l , Mmp3 , Multiple epiphyseal dysplasia , Nail-patella syndrome , Osteochondritis dissecans , Spondyloepiphyseal dysplasia tarda , Tgfb1 , Thalassemia , Wilson disease
Hematologic
Diabetes , Hemochromatosis , Thalassemia
Iatrogenic
Meniscectomy , Surgery
Infectious Disease
Syringomyelia , Tabes dorsalis , Viral hepatitis
Musculoskeletal/Orthopedic
Aseptic necrosis of bone , Asymmetric leg length , Avascular necrosis , Chondrocalcinosis 1 , Chondrocalcinosis 2 , Developmental dysplasia of the hip , Ehlers-danlos syndrome , Familial chondrocalcinosis , Fracture of bone , Joint injury , Meniscectomy , Multiple epiphyseal dysplasia , Muscle dysfunction , Osteochondritis dissecans , Syringomyelia , Tabes dorsalis
Neurologic
No underlying causes
Nutritional/Metabolic
Diabetes , Obesity
Obstetric/Gynecologic
No underlying causes
Oncologic
Pituitary cancer , Pituitary tumors
Ophthalmologic
No underlying causes
Overdose/Toxicity
No underlying causes
Psychiatric
No underlying causes
Pulmonary
No underlying causes
Renal/Electrolyte
No underlying causes
Rheumatology/Immunology/Allergy
Allergies , Aseptic necrosis of bone , Avascular necrosis , Chondrocalcinosis 1 , Chondrocalcinosis 2 , Crystal deposition , Gout , Lupus , Rheumatoid arthritis , Satoyoshi syndrome
Sexual
No underlying causes
Trauma
Developmental dysplasia of the hip , Fracture of bone , Joint injury , Physical trauma , Trauma
Urologic
Alkaptonuria
Miscellaneous
Aging
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References
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