Antiphospholipid syndrome risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
The most common risk factors of antiphospholipid syndrome risk factors are history of autoimmune diseases like SLE, Sjogren's syndrome, Infections- Cytomegalovirus, Human Immunodeficiency Virus, Parvovirus B-19, Hepatitis C Virus, Lymes, Syphilis, E.coli, Leptospirosis, Drugs- Hydralazine, Quinidine, Phenytoin, and Amoxicillin, Family history- antiphospholipid syndrome is common in patients with a family history of antiphospholipid syndrome.
Risk Factors
The Antiphospholipid syndrome risk factors are as follows:[1][2][3][4][5]
Common risk factors
- History of autoimmune disease:
- SLE
- Sjogren's syndrome
- Infections:
- Cytomegalovirus
- Human Immunodeficiency Virus
- Parvovirus B-19
- Hepatitis C Virus
- Lymes
- Syphilis
- E.coli
- Leptospirosis.
- Drugs:
- Hydralazine
- Quinidine
- Phenytoin
- Amoxicillin
- Family history: Antiphospholipid syndrome is common in patients with a family history of antiphospholipid syndrome.
Less common risk factors:
- Pregnancy
- Obesity
- Hypertension
- Sedentary lifestyle
- Recent surgery
- Tobacco Smoking
- Oral contraceptives
- Estrogen therapy
- Hyperlipidemias
- Cancer
References
- ↑ Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA (October 2010). "Antiphospholipid syndrome". Lancet. 376 (9751): 1498–509. doi:10.1016/S0140-6736(10)60709-X. PMID 20822807.
- ↑ Willis R, Harris EN, Pierangeli SS (June 2012). "Pathogenesis of the antiphospholipid syndrome". Semin. Thromb. Hemost. 38 (4): 305–21. doi:10.1055/s-0032-1311827. PMID 22510982.
- ↑ Gris JC, Brenner B (November 2013). "Antiphospholipid antibodies: neuropsychiatric presentations". Semin. Thromb. Hemost. 39 (8): 935–42. doi:10.1055/s-0033-1357488. PMID 24129681.
- ↑ Koike T (October 2014). "My contribution, my dream - a look at the future of APS". Lupus. 23 (12): 1332–4. doi:10.1177/0961203314534306. PMID 25228741.
- ↑ Sciascia S, Cuadrado MJ, Khamashta M, Roccatello D (May 2014). "Renal involvement in antiphospholipid syndrome". Nat Rev Nephrol. 10 (5): 279–89. doi:10.1038/nrneph.2014.38. PMID 24642799.