Mixed connective tissue disease laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

Laboratory findings consistent with the diagnosis of MCTD include:^[1]^[2]
- Antibodies against the U1-ribonucleoprotein complex (anti U1RNP)
- Rheumatoid factor (RF)
- High CRP levels^[3]
- Hypergammaglobulinemia^[4]

↑ Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (July 2006). "Rheumatoid factor isotypes in mixed connective tissue disease". Clin. Rheumatol. 25 (4): 572–4. doi:10.1007/s10067-005-0185-y. PMID 16391886.
↑ Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A (November 2004). "[Undifferentiated, overlapping and mixed connective tissue diseases]". Med Clin (Barc) (in Spanish; Castilian). 123 (18): 712–7. PMID 15563821.
↑ Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I (October 1998). "Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease". J. Autoimmun. 11 (5): 503–8. doi:10.1006/jaut.1998.0236. PMID 9802936.
↑ Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M (1993). "More evidence of distinctive features of mixed connective tissue disease". Scand. J. Rheumatol. 22 (2): 63–8. PMID 8480140.