Ankylosing spondylitis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
There are no specific diagnostic laboratory findings associated with ankylosing spondylitis(AS).There are certain blood tests that can check for markers of inflammation.Most of the time patients with AS their blood is tested for the HLA-B27 gene, but again most people who are positive for that gene don't have ankylosing spondylitis.Other laboratory findings consistent with ankylosing spondylitis(AS) include ESR and CRP levels.
Laboratory Findings[1][2]
- There are no specific diagnostic laboratory findings associated with ankylosing spondylitis(AS) and most the tests are non-specific.
- Human leukocyte antigen (HLA)-B27 is positive in most the patients, but not invariably so.[3]
- laboratory findings consistent with ankylosing spondylitis(AS) include ESR and CRP levels.[4]
- Some patients with active AS are positive for normochromic normocytic anemia.
Increase in:
- C-reactive protein (CRP) and
- Erythrocyte sedimentation rate (ESR).
References
- ↑ Rudwaleit M, van der Heijde D, Khan MA, Braun J, Sieper J (May 2004). "How to diagnose axial spondyloarthritis early". Ann. Rheum. Dis. 63 (5): 535–43. doi:10.1136/ard.2003.011247. PMC 1754994. PMID 15082484.
- ↑ Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A (December 2002). "Ankylosing spondylitis: an overview". Ann. Rheum. Dis. 61 Suppl 3: iii8–18. PMC 1766729. PMID 12381506.
- ↑ de Winter JJ, van Mens LJ, van der Heijde D, Landewé R, Baeten DL (September 2016). "Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis". Arthritis Res. Ther. 18: 196. doi:10.1186/s13075-016-1093-z. PMC 5009714. PMID 27586785.
- ↑ Rudwaleit M, Haibel H, Baraliakos X, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J (March 2009). "The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort". Arthritis Rheum. 60 (3): 717–27. doi:10.1002/art.24483. PMID 19248087.