Cryoglobulinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]
Overview
History
Symptoms
Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:
- Difficulty breathing
- Symptoms related to glomerulonephritis including blood in urine, foamy urine, and edema.
- Renal involvement is more common in type II than in type III.
- Purpura or skin ulcer
- Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
- Myalgia
- Fatigue
- Blurring/loss of vision
- Diplopia
- Confusion
- Nonspecific constitutional symptoms