Cryoglobulinemia natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Complications include:

Bleeding in the digestive tract (rare)
Heart disease (rare)
Infections of ulcers
Kidney failure
Liver failure
Skin death
Death
Low-grade Non-Hodgkins lymphomas may occur with increased frequency among these patients.

Cryoglobulinemia is not usually deadly. However, if the kidneys are affected, the outlook is poor.