Cryoglobulinemia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Overview

In 1966, Meltzer and Franklin were the first ones to describe Meltzer triad which includes following clinical manifestations, purpura, arthralgia, and weakness.

Historical Perspective

• In 1966, Meltzer and Franklin were the first ones to describe Meltzer triad which includes following clinical manifestations, purpura, arthralgia, and weakness.
• This triad of clinical manifestations was seen in the patients having essential mixed cryoglobulinemia.