Myasthenia gravis classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]
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Overview
Classification
Myasthenia gravis may be classified into 3 subtypes based on presence of autoantibodies.
Pure ocular form
Ocular symptoms are the initial symptom in most of the MG cases. In about 15 percent of these patients this initial symptom will not progress to generalized disease after 2 years and they will classify as pure ocular form of the Myasthenia gravis. In approximately 50 percent of these patients we can’t detect antibodies by classical assay and we need to detect them through cell-based assay.(30)
Generalized form with anti-AChR antibodies
- Early onset myasthenia gravis (onset of the disease before the age of 50 (EOMG))
- Late onset myasthenia gravis (onset of the disease after the age of 50 (LOMG))
The forms without classical anti-AChR antibodies
- The form with anti-anti-MuSK antibodies
- The form with anti-LRP4 antibodies
- The form with clustered AChR antibodies