Leiomyosarcoma
Leiomyosarcoma Microchapters |
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Leiomyosarcoma On the Web |
American Roentgen Ray Society Images of Leiomyosarcoma |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Leiomyosarcoma from other Diseases:
Epidemiology and Demographics:
Risk Factors:
Natural History, Complications and Prognosis
- The majority of patients with leiomyosarcoma remain asymptomatic for decades.
- Most leiomyosarcomas are diagnosed incidentally at an advanced stage.
- They are invariably aggressive and associated with the poor prognosis.
Prognosis: The prognosis of leiomyosarcoma is poor and it depends on varying factors:
- Tumor size
- Tumor location
- Tumor type/Grade
- DNA content
- Hormonal receptor status
- cellular division and mitotic rate
- local and distant extension
Survival Rate of Leiomyosarcoma by staging:
Stage | Percentage |
stage 1 | 60 |
stage 2 | 35 |
stage 3 | 28 |
stage 4 | 15 |
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Leiomyosarcoma treatment consist of multidisciplinary approach and is best carried out at the specialized hospital setting.
Medical Therapy | Surgery | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies