Paroxysmal nocturnal hemoglobinuria other diagnostic studies

Paroxysmal nocturnal hemoglobinuria Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There are no other diagnostic studies associated with [disease name].

OR

[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

• [Flow cytometry] is the diagnostic study of choice to confirm or exclude PNH, but has to be performed only after confirming coomb's negative intravascular hemolysis. Findings include reduced levels or absent glycosylphosphatidylinositol (GPI) linked proteins on surface of blood cells. Commonly detected GPI linked proteins include CD59 and CD55.

• Other diagnostic studies not required for diagnosis include:
  1. [Bone marrow biopsy]
     • Indication: Pancytopenia
     • Findings: hypocellular or normocellular or hypercellular marrow