Sideroblastic anemia differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.
Overview
Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.
Differential Diagnosis
Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.[1][2]
Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.
- ALA Dehydratase Deficiency Porphyria
- Acute Myeloid Leukemia (AML)
- Congenital Erythropoietic Porphyria
- Hereditary Coproporphyria
- Iron Deficiency Anemia
- Myelodysplastic Syndrome
- Secondary Thrombocytosis
References
- ↑ Bottomley SS, Muller-Eberhard U (October 1988). "Pathophysiology of heme synthesis". Semin. Hematol. 25 (4): 282–302. PMID 3064310.
- ↑ Cattivelli K, Campagna DR, Schmitz-Abe K, Heeney MM, Yaish HM, Caruso Brown AE, Kearney S, Walkovich K, Markianos K, Fleming MD, Neufeld EJ (May 2017). "Ringed sideroblasts in β-thalassemia". Pediatr Blood Cancer. 64 (5). doi:10.1002/pbc.26324. PMC 5697724. PMID 27808451.