Mantle cell lymphoma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
The causes of mantle cell lymphoma have not been clearly identified.
Causes
- Mantle cell lymphoma, like most malignancies, results from the acquisition of a combination of (non-inherited) genetic mutations in somatic cells.
- The typical mutation occurring in mantle cell lymphoma causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
- Recently, weak associations have been observed in the development of mantle cell lymphoma with the following:
- With exposure to European strains of Borellia burgdoferi.
- Family history of hematologic malignancy.
- Genetic polymorphisms in the pro-inflammatory cytokine IL-10.
However, factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development.