Multiple sclerosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Irfan Dotani
Overview
Multiple sclerosis was first described by a neurologist, Dr. Jean Martin Charcot in 1868 and named sclerose en plaque. The signs and symptoms including dysarthria, ataxia, and tremor were called 'Charcot’s triad'.
Historical Perspective
Discovery
- Multiple sclerosis was first described by a neurologist, Dr. Jean martin Charcot in 1868. Previously, Dr. Robert Hooper (1773-1835), Robert Carswell (1793-1857), and Jean Cruveilhier (1791-1873) had noticed some of the MS clinical manifestations, but for the first time, Dr. Charcot described it as a distinct disease and named sclerose en plaque.
- The signs and symptoms including dysarthria, ataxia, and tremor were called charcot’s triad.
Landmark Events in the Development of Treatment Strategies
Famous Cases
One of the first suspected MS patients in history is Saint Lidwina (1380-1433). She had symptoms such as pain, lower extremities weakness, and vision loss.[1][2] The other MS suspected patient in history is Augustus Frederick d’este (1794-1848). His symptoms began at the age of 28 with vision loss, bladder dysfunction, numbness, weakness of legs and sexual dysfunction.[3]
References
- ↑ Charcot, J. Histologie de la sclerose en plaques. Gazette des hopitaux, Paris, 1868; 41: 554–555.
- ↑ Poser C (1994). "The dissemination of multiple sclerosis: a Viking saga? A historical essay". Ann. Neurol. 36 Suppl 2: S231–43. PMID 7998792.
- ↑ Firth, D (1948). The Case of August D`Esté. Cambridge: Cambridge University Press.