Mantle cell lymphoma laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing, FISH and PCR
Laboratory tests
Laboratory tests for mantle cell lymphoma include:
- Complete blood count (CBC) with differential count
- Comprehensive metabolic panel
- LDH levels
- Hepatitis B testing if treatment with rituximab is planned
- Uric acid levels
- Beta-2-microglobulin
- Pregnancy testing in woman of child-bearing age
- Flow cytometry
- Immunohistochemistry
- CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
- Overexpression of CYCLIN D
- SOX11 expression
- Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
- Mutation or deletions of ATM gene
- Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used.