Guillain-Barré syndrome epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyamvada Singh, MBBS [2]

Overview

Guillain-Barré syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy affecting the peripheral nervous system, usually triggered by an acute infectious process. The incidence is approximately 1.2 - 3 / 100,000 persons per year across the world. It is commoner in males compared to female and has two peaks (15-35 years and 50-75 years). Incidence is similar across different races.

Epidemiology and Demographics

Incidence

Incidence vary from 0.4 to 4.0 cases per population of 100 000.^[1]

Case mortality rate

in previous studies, Guillain-Barre syndrome mortality rate was 2.58%.^[2]

Age

It can happen in any age group but it’s more common in late adolescence.
The reason behind this is that immune suppressor mechanisms will decrease with age.^[1]

Races

It was demonstrated in one study that the incidence rate for whites were 0.44 and for blacks were 0.28 per 100,000, but it seems that despite all of these, the incidence is similar across different races.^[3]

Gender

It is more common among males compared to females. Male to female ratio 1.5:1.^[1]

References

↑ ^1.0 ^1.1 ^1.2 Hughes RA, Rees JH (December 1997). "Clinical and epidemiologic features of Guillain-Barré syndrome". J. Infect. Dis. 176 Suppl 2: S92–8. PMID 9396689.
↑ Alshekhlee A, Hussain Z, Sultan B, Katirji B (April 2008). "Guillain-Barré syndrome: incidence and mortality rates in US hospitals". Neurology. 70 (18): 1608–13. doi:10.1212/01.wnl.0000310983.38724.d4. PMID 18443311.
↑ Hurwitz ES, Holman RC, Nelson DB, Schonberger LB (February 1983). "National surveillance for Guillain-Barré syndrome: January 1978-March 1979". Neurology. 33 (2): 150–7. PMID 6681655.

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[pmid9396689-1] 1.0 ^1.1 ^1.2 Hughes RA, Rees JH (December 1997). "Clinical and epidemiologic features of Guillain-Barré syndrome". J. Infect. Dis. 176 Suppl 2: S92–8. PMID 9396689.

[pmid18443311-2] Alshekhlee A, Hussain Z, Sultan B, Katirji B (April 2008). "Guillain-Barré syndrome: incidence and mortality rates in US hospitals". Neurology. 70 (18): 1608–13. doi:10.1212/01.wnl.0000310983.38724.d4. PMID 18443311.

[pmid6681655-3] Hurwitz ES, Holman RC, Nelson DB, Schonberger LB (February 1983). "National surveillance for Guillain-Barré syndrome: January 1978-March 1979". Neurology. 33 (2): 150–7. PMID 6681655.

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