ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3gene.[1][2]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.[3]
↑Puertollano, R; Randazzo P A; Presley J F; Hartnell L M; Bonifacino J S (Apr 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. United States. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. ISSN0092-8674. PMID11301005.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID8590280.
Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID10814529.
Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID11301005.
Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. doi:10.1126/science.1060750. PMID11387475.
Misra S, Puertollano R, Kato Y, et al. (2002). "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains". Nature. 415 (6874): 933–7. doi:10.1038/415933a. PMID11859375.
Kato Y, Misra S, Puertollano R, et al. (2002). "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nat. Struct. Biol. 9 (7): 532–6. doi:10.1038/nsb807. PMID12032548.
Doray B, Ghosh P, Griffith J, et al. (2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science. 297 (5587): 1700–3. doi:10.1126/science.1075327. PMID12215646.
Wakasugi M, Waguri S, Kametaka S, et al. (2003). "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochem. Biophys. Res. Commun. 306 (3): 687–92. doi:10.1016/S0006-291X(03)01032-5. PMID12810073.
He X, Zhu G, Koelsch G, et al. (2003). "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry. 42 (42): 12174–80. doi:10.1021/bi035199h. PMID14567678.
Shiba Y, Katoh Y, Shiba T, et al. (2004). "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination". J. Biol. Chem. 279 (8): 7105–11. doi:10.1074/jbc.M311702200. PMID14660606.