Laryngeal cancer history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
The hallmark of laryngeal cancer is hoarseness. A positive history of neck lump and hoarseness is suggestive of laryngeal cancer. Based on the location of the tumor, symptoms may differ but commonly includes hoarseness or other voice changes, lump in the neck, sore throat, and persistent cough
History and Symptoms
There can be a patient history of the following:
- Alcohol[1][2]
- Tobacco products[1][3][4]
- Viral infection: EBV[5] ,HPV, hepatitis C virus (HCV)[6], and human immunodeficiency virus (HIV) and Herpes[7]
- Immunodeficiency: HIV or solid organ transplantation has been associated with an increased risk of cancer in the head and neck region[8]
- Betel nut chewing [9]
- Pesticides, man-made mineral vitreous fibers (MMMF), polycyclic aromatic hydrocarbons
- Mouthwash [14]
Based on the location of the tumor, symptoms may differ but commonly include:[15][16]
- Hoarseness or other voice changes
- Lump in the neck
- Sore throat
- Persistent cough
- Stridor
- Bad breath
- Earache
- Odynophagia
- Dysphagia
- Chronic cough
- Hemoptysis
- Dyspnea
- Otalgia
References
- ↑ 1.0 1.1 Andre K, Schraub S, Mercier M, Bontemps P (September 1995). "Role of alcohol and tobacco in the aetiology of head and neck cancer: a case-control study in the Doubs region of France". Eur. J. Cancer, B, Oral Oncol. 31B (5): 301–9. PMID 8704646.
- ↑ De Stefani E, Boffetta P, Oreggia F, Fierro L, Mendilaharsu M (March 1998). "Hard liquor drinking is associated with higher risk of cancer of the oral cavity and pharynx than wine drinking. A case-control study in Uruguay". Oral Oncol. 34 (2): 99–104. PMID 9682771.
- ↑ Lewin F, Norell SE, Johansson H, Gustavsson P, Wennerberg J, Biörklund A, Rutqvist LE (April 1998). "Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck: a population-based case-referent study in Sweden". Cancer. 82 (7): 1367–75. PMID 9529030.
- ↑ Spitz MR (June 1994). "Epidemiology and risk factors for head and neck cancer". Semin. Oncol. 21 (3): 281–8. PMID 8209260.
- ↑ Kobayashi I, Shima K, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Ohishi M, Sakai H (September 1999). "Prevalence of Epstein-Barr virus in oral squamous cell carcinoma". J. Pathol. 189 (1): 34–9. doi:10.1002/(SICI)1096-9896(199909)189:1<34::AID-PATH391>3.0.CO;2-4. PMID 10451485.
- ↑ Mahale P, Sturgis EM, Tweardy DJ, Ariza-Heredia EJ, Torres HA (August 2016). "Association Between Hepatitis C Virus and Head and Neck Cancers". J. Natl. Cancer Inst. 108 (8). doi:10.1093/jnci/djw035. PMC 5017939. PMID 27075854.
- ↑ Das CM, Schantz SP, Shillitoe EJ (May 1993). "Antibody to a mutagenic peptide of herpes simplex virus in young adult patients with cancer of the head and neck". Oral Surg. Oral Med. Oral Pathol. 75 (5): 610–4. PMID 8387664.
- ↑ Rabinovics N, Mizrachi A, Hadar T, Ad-El D, Feinmesser R, Guttman D, Shpitzer T, Bachar G (February 2014). "Cancer of the head and neck region in solid organ transplant recipients". Head Neck. 36 (2): 181–6. doi:10.1002/hed.23283. PMID 23554129.
- ↑ Guha N, Warnakulasuriya S, Vlaanderen J, Straif K (September 2014). "Betel quid chewing and the risk of oral and oropharyngeal cancers: a meta-analysis with implications for cancer control". Int. J. Cancer. 135 (6): 1433–43. doi:10.1002/ijc.28643. PMID 24302487.
- ↑ Olsen J, Sabroe S (June 1984). "Occupational causes of laryngeal cancer". J Epidemiol Community Health. 38 (2): 117–21. PMID 6747509.
- ↑ Battista G, Belli S, Comba P, Fiumalbi C, Grignoli M, Loi F, Orsi D, Paredes I (November 1999). "Mortality due to asbestos-related causes among railway carriage construction and repair workers". Occup Med (Lond). 49 (8): 536–9. PMID 10658307.
- ↑ Roh S, Park S, Tae G, Song J (2016). "A case of laryngeal cancer induced by exposure to asbestos in a construction site supervisor". Ann Occup Environ Med. 28: 34. doi:10.1186/s40557-016-0114-3. PMC 4976513. PMID 27504188.
- ↑ Vaughan TL, Stewart PA, Davis S, Thomas DB (September 1997). "Work in dry cleaning and the incidence of cancer of the oral cavity, larynx, and oesophagus". Occup Environ Med. 54 (9): 692–5. PMC 1128846. PMID 9423585.
- ↑ Boffetta P, Hayes RB, Sartori S, Lee YC, Muscat J, Olshan A, Winn DM, Castellsagué X, Zhang ZF, Morgenstern H, Chen C, Schwartz SM, Vaughan TL, Wunsch-Filho V, Purdue M, Koifman S, Curado MP, Vilensky M, Gillison M, Fernandez L, Menezes A, Daudt AW, Schantz S, Yu G, D'Souza G, Haddad RI, La Vecchia C, Hashibe M (July 2016). "Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium". Eur. J. Cancer Prev. 25 (4): 344–8. doi:10.1097/CEJ.0000000000000179. PMC 4752930. PMID 26275006.
- ↑ Jones TM, De M, Foran B, Harrington K, Mortimore S (May 2016). "Laryngeal cancer: United Kingdom National Multidisciplinary guidelines". J Laryngol Otol. 130 (S2): S75–S82. doi:10.1017/S0022215116000487. PMC 4873912. PMID 27841116.
- ↑ Jovanović MB (2008). "[Diagnosis of laryngeal carcinoma]". Med. Pregl. 61 (11–12): 591–5. PMID 19368278.